CONICET | Buscador de Institutos y Recursos Humanos

A new mathematical model for the prediction of the heterogeneous hydrolytic degradation of PLGA-based microspheres was developed. The model takes into account the autocatalytic effect of carboxylic groups and polymer composition on the degradation rate. It is based on mass balances for the different species, considering the kinetic and mass transport phenomena involved. The model estimates the evolutions of average molecular weights, mass loss and morphological changes of particles during degradation, and it was validated with novel experimental data. Theoretical predictions are in good agreement with experimental results. The model is able to predict the effect of particle size and molecular weight on the degradation of PLGA-based microspheres and estimates the morphological changes of the particles due to the autocatalytic effect.