"Modeling of Drug from Erodible and Non-erodible Laminated Planar Devices info Finite External Medium"

IGNACIO M. HELBLING; JUAN C.D. IBARRA; JULIO A. LUNA; MAR¨ªA I. CABRERA; RICARDO J.A. GRAU

JOURNAL OF MEMBRANE SCIENCE

Elsevier

Lugar: Shannon, Co. Clare, Ireland; Año: 2010 vol. 350 p. 10 - 18

0376-7388

Analytical solutions based on the pseudo-steady state approximation (PSSA) were derived for the case of controlled dispersed-drug release from planar matrices with and without erosion, through a membrane, and taking into account the existence of a diffusion boundary layer and finite release medium. The solutions can be applied to a broad range of situations from drug release in a finite or infinite medium, matrices with or without erosion, in the presence or absence of a membrane, and in the presence or absence of a stagnant liquid layer. The prediction is accurate for the cases in which the initial drug load is higher than the drug solubility in the polymer (e.g. A/Cs >3) till the entire dispersed drug is dissolved. The dependence on the release kinetics with different parameters was simulated and provides a theoretical foundation for the design of dispersed drug release devices.