Optimal experimental design for process optimization with stochastic binary outcomes

ESTEFANÍA COLOMBO; MARTIN LUNA; ERNESTO MARTÍNEZ

Rosario

Simposio; 44 JAIIO; 2015

SADIO

Effective control of the end-use properties in order to guaranteeproduct quality is of paramount importance. This is especially valuable forproducts such as pharmaceuticals, polymers and nanomaterials. There are plentyof innovative processes whose principles of operation are unknown and forwhich is not possible to develop reliable models due to time and cost. Despitethis, it is important to know the optimum operating zone where the processshould work to ensure that the end product meets the required properties. Toaddress this issue, a run-to-run optimization approach is proposed to find thereduced region of operation which guarantees obtaining end-use properties withhigh probability when a first-principles model for the batch process is not available a priori. In order to evaluate the effectiveness of the methodology to find optimal policies for runs involving stochastic binary outcomes, the well-known example of the emulsion polymerization of styrene has been addressed. Results obtained demonstrated that the proposed method is a powerful tool for optimal design of experiments aiming to guarantee end-use product properties.