PHOTOACUSTIC STUDY OF THE AGREGATION OF GOLD NANOPARTICLES BY Ru(II) COMPLEXES

MAXIMILIANO BURGOS PACI; GARCIA, FACUNDO; BILMES, GABRIEL; DAVID GARA, PEDRO M.; EDUARDO CORONADO

Bilbao

Conferencia; 19th International Conference on Photoacoustic and Photothermal Phenomena; 2017

The different photophysical and photochemical properties of different nanosystems (NS) have allowed the development of nanomedicine as an effective tool in the detection and phototherapeutic treatment of diseases. Recently, studies have been developed regarding the use of NS for the therapeutic treatment of neoplastic diseases. This treatment is known as photothermal therapy, because is the relaxation of the excited state that generates a local increase in the temperature of NS. So the study of the photoacoustic and photothermal properties of different NS is fundamental for their understanding. Previous studies have shown that nanoaggregate plasmon has an increase of the electric field in the gap zone. This increase in the field could lead to a localized increase in temperature and, therefore, an increase in the photoacoustic signal. [1].In this work the aggregation process in NPs by cationic complexes are studied by laser-induced photoacoustic measurements. The systems studied are Au NPs with Ru(II) complex acting aggregation agent. Figure 1 shows the linear relationship between the amplitude of the first photoacoustic signals (H) as a function of laser fluence for water solutions of for increasing aggregation of Au-NPs.The results show that at short aggregation times a large number of small nanoaggregates exist and that these are relatively stable. Unlike other aggregating agents, Ruthenium (II) complexes would have the ability to generate ordered aggregates with controlled kinetics.