CIOP   05384
CENTRO DE INVESTIGACIONES OPTICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
SCOP AND PHOTODYNAMIC THERAPY IN TISSUES INFECTED BY HPV
Autor/es:
ALBANESI, ESTELA I.; MARÍA EUGENIA ETCHEVERRY; CORTI, AGUSTINA; POTECA, HORACIO; MARIO GARAVAGLIA
Lugar:
Trieste
Reunión:
Congreso; ICGEB DNA TUMOUR VIRUS MEETING 2015; 2015
Institución organizadora:
INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY
Resumen:
Worldwide, every two minutes a woman dies of cervical cancer (CC); 500.000 new CC cases are reported annually with and 270.000 death/year. In Latin America and the Caribbean more than 30,000 women die annually from CC, generating more years of life lost than breast cancer, tuberculosis, and AIDS combined. In Argentina 5.000 new CC appear/year, with 2,000 deaths were reported. (ScOp) is based on the observation of tissues fluorescence, for analyzing ?in situ? biochemical changes of healthy tissue and HPV affected tissues. To validate the ScOp procedure an exhaustive research labor is needed to correlate its results with that of the conventional extractive biopsy. If that occur, ScOp would give us a fast and reliable diagnosis avoiding the possible spread of malignant cells and the typical delays of conventional biopsy. Thus, ScOp can contribute to medical diagnoses of cervical HPV diseases related which has high rates of morbid-mortality. So, as we are verifying that ScOp is useful in the early detection of cancer, we propose the following two hypotheses: a)Minimalist hypothesis: ScOp can distinguish between HR-HPV and LR-HPV infections,b)Maximalist hypothesis: ScOp can distinguish between HPV genotypes infections. Our final challenge is to prove that ScOp have higher sensitivity and the same specificity as the histopathologic techniques which can lead to "gold standard" by its simplicity and effectiveness, as it was desired in the International Workshop on HPV : "Human Papillomavirus : From Basic Biology to Cervical Cancer Prevention", organized by the ICGEB in Rosario, Argentina, 2014 .In other vein, optical diagnostic study of tissue natural fluorescence can be significantly enhanced by the administration of specific photosensitizers, whose molecules are preferentially located in neoplastic cells when they are illuminated by the same laser or LEDs. This procedure of induced fluorescence observation of tumoral cells is called Photodynamic Diagnosis (PDD). This procedure also opens the alternative of introducing Photodynamic Therapy (PDT) of lesions HR-HPV related, as applies to other tumors like head and neck, lung, esophagus, bladder, etc.