A model of cells recruited by a spatiotemporal signalling pattern inducing cell cycle reduction during axolotl spinal cord regeneration

AIDA RODRIGO ALBORS; ELLY TANAKA; EMANUEL CURA COSTA; OSVALDO CHARA

Boston

Conferencia; Tenth International Conference on Complex Systems; 2020

New England Complex Systems Institute

Axolotls own outstanding regeneration capabilities after injury. 8 days after tail amputation (dpa) this lovely animal is able to recover more than 2mm of spinal cord. Little is known about the mechanisms underlying the process. In previous studies, we found that tail amputation leads to a cell cycle reduction in cells close to the amputation plane (Rodrigo Albors et al., 2015). Posteriorly, we identified a high-proliferation zone arising 4 dpa and demonstrated that cell cycle acceleration is the major driver of regenerative growth (Rost et al., 2016). What triggers this spatiotemporal pattern of cell proliferation has not been yet elucidated. Here, using a data-driven modelling approach, we recapitulate the emergence of the tissue outgrowth in terms of a cell-based regulation of the cell cycle control both in space and time.