Data-driven multi-scale model of tissue regeneration in axolotl

CHARA OSVALDO

Lisboa

Conferencia; 11th European Conference on Mathematical and Theoretical Biology (ECMTB); 2018

European Society on Mathematical and Theoretical Biology (ESMTB)

In striking contrast with humans, a number of species have the ability to regenerate sub-stantial parts of their body after tissue amputation. Among the vertebrates, the axolotl(Ambystoma mexicanum) is able to regenerate the limb and the spinal cord, among otherbody parts. By using a combination of mathematical modeling with imaging and cell track-ing we identified key cellular mechanisms underlying spinal cord and limb regeneration inthe axolotl. In this talk I will show recent results from our lab suggesting that tissue am-putation initiates a regeneration program that mirrors development. To interpret theseresults I will discuss a multi-scale model aimed to understand the regenerative responses inthe axolotl in terms of a signaling process triggering acceleration of the cell cycle and celldisplacements.