IFLYSIB   05383
INSTITUTO DE FISICA DE LIQUIDOS Y SISTEMAS BIOLOGICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
On the negative feedback of extracellular ADP on ATP release: a theoretical approach
Autor/es:
CHARA OSVALDO; PAFUNDO DIEGO; SCHWARZBAUM PABLO JULIO
Lugar:
Buzios, Brazil
Reunión:
Congreso; VII Iberoamerican Congress of Biophysics 2009; 2009
Resumen:
Under hypotonicity goldfish hepatocytes swell followed by avolume regulatory decrease (RVD). The initial swelling triggersATP release, followed by activation by extracellular ATP of asignaling process enabling RVD. ATP can also be hydrolysed byectonucleotidases to ADP in the extracellular space. Sinceextracellular ADP has been postulated to inhibit ATP release, weused mathematical modeling to assess whether extracellular ADPcan inhibit the release of ATP.