IFLYSIB   05383
INSTITUTO DE FISICA DE LIQUIDOS Y SISTEMAS BIOLOGICOS
Unidad Ejecutora - UE
artículos
Título:
The Behavior of the Hydrophobic Effect under Pressure and Protein Denaturation
Autor/es:
J. RAUL GRIGERA; ANDRES N. MCCARTHY
Revista:
BIOPHYSICAL JOURNAL
Editorial:
CELL PRESS
Referencias:
Año: 2009 vol. 98
ISSN:
0006-3495
Resumen:
ABSTRACT It is well known that proteins denature under high pressure. The mechanism that underlies such a process is stillnot clearly understood, however, giving way to controversial interpretations. Using molecular dynamics simulation on systemsthat may be regarded experimentally as limiting examples of the effect of high pressure on globular proteins, such as lysozymeand apomyoglobin, we have effectively reproduced such similarities and differences in behavior as are interpreted from experiment.From the analysis of such data, we explain the experimental evidence at hand through the effect of pressure on the changeof water structure, and hence the weakening of the hydrophobic effect that is known to be the main driving force in protein folding