Development of antimicrobial hybrid mesoporous silver phosphateepectin microspheres for control release of levofloxacin

BAYON, BERNARDO; BUCALA, VERONICA; CASTRO, GUILLERMO

MICROPOROUS AND MESOPOROUS MATERIALS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 226 p. 71 - 78

1387-1811

Stable spherical Ag3PO4 microparticles were chemically synthesized under controlled physicochemical conditions. The microparticles were characterized by shape and size distribution, as well as the biophysical properties. However, scanning electron microscopies of the silver microparticles showed the presence of salt detritus with many secondary structures and displayed bimodal size distribution between 0.9-1.0 µm and 1.5 to 1.8 µm. Meanwhile, synthesis of silver phosphate microparticles in presence of pectin not only change the surface morphology of the particles but also produce narrow particle dried size between 1.3 to 1.5 µm with 90% population and increase of pore size in about 20% to 30%. The results were confirmed with light diffraction, optical, scanning and transmission electron microscopies. X-Ray diffraction established the presence of silver phosphate showing the same profiles in presence and absence of pectin. Effect of silver phosphate hybrid microparticles loaded with levofloxacin against Escherichia coli, and Staphylococcus aureus showed strong bactericidal activity compared with the bacteriostatic effect of free levofloxacin. The results are suggesting that Ag3PO4?pectin hybrid microparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.