CIDCA   05380
CENTRO DE INVESTIGACION Y DESARROLLO EN CRIOTECNOLOGIA DE ALIMENTOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Hepatic recovery alter damage produced by sub-chronic intoxication with the cyanotoxin microcystin LR
Autor/es:
1. ANDRINOLO, D SEDAN D, TELESE L, AURA C, MARRA C, ALANIZ M GIANNUZZI L
Lugar:
Rio de Janeiro
Reunión:
Congreso; VII International Conference on Cyanobacteria 5-10 August 2007 Rio de Janeiro, Brasil.; 2007
Institución organizadora:
UFRJ
Resumen:
The effect of sub-chronic exposure of intraperitoneal injections of microcystin-LR (MC-LR) on microscopic
tissue architecture, hepatic function and lipid peroxidation has been studied in liver and kidney of mice. Mice
were treated i.p. with 25 ìg of pure MC-LR/kg body weight or saline solution for one month (every two days)
with the aim of producing an inflictive stage with evident damage. Histopathological analysis of dissected livers
of mice showed a disrupted lobar architecture and the development of cytoplasmatic vacuoles. According to
this, a significant increase in hepatic lipid content and in lipid peroxidation levels in liver and kidney was found
in MC-LR treated animals when compared with controls. Moreover, serum alkaline phosphatase and aspartate
aminotransferase activities showed a significant alteration in MC-LR treated animals.After damage, progression
or recovery were studied for one and two months of wash out. The recovery from liver damage was evident at
cytological and physiological level, only the recovery of lobar architecture was incomplete along the period
investigated. In conclusion, the present study demonstrates the ability of hepatic tissue to recover from
damage produced by sub-chronic MC-LR administration. The dynamic interplay between damage and tissue
repairing response in determining the ultimate outcome of toxicity should be considered in risk assessment
studies