Vanadium and Bone Vanadium and Bone. Relevance of Vanadium Compounds in Bone Cells

ETCHEVERRY SB AND BARRIO DA

Vanadium: The versatile metal

American Chemical Society

Lugar: Washington DC 20036; Año: 2007; p. 204 - 216

Bone is one of the main tissues of vanadium storage in vertebrates. Vanadium compounds exert interesting biological effects as well as potential pharmacological actions. We review herein the bioactivity of vanadium with emphasis in results obtained in bone related cells in culture. Vanadium compounds behaved as antitumoral agents, as growth factor mimetic compounds and as osteogenic drugs. We report for the first time, the effects of a complex of vanadyl(IV) cation with Trehalose on long-term cultures of non transformed osteoblasts. The complex induced cell proliferation, glucose consumption, osteoblast differentiation and the mineralization of the extracellular matrix.