CIDCA   05380
CENTRO DE INVESTIGACION Y DESARROLLO EN CRIOTECNOLOGIA DE ALIMENTOS
Unidad Ejecutora - UE
artículos
Título:
The use of saliva as biological fluid in relative bioavailability studies: comparison and correlation with plasma results
Autor/es:
RUIZ, M. ESPERANZA; CONFORTI, PAULA; FAGIOLINO, PIETRO; VOLONTÉ, M. GUILLERMINA
Revista:
Biopharmaceutics and Drug Disposition
Editorial:
John Wiley & Sons, Ltd.
Referencias:
Año: 2010 vol. 31 p. 476 - 485
ISSN:
1099-081X
Resumen:
The aim of the present study was to present new evidence supporting the use of saliva as biological fluid in relative bioavailability studies. Carbamazepine was chosen as a model drug because of its suitability for salivary therapeutic drug monitoring and its well-documented plasma bioavailability. A relative bioavailability study in saliva of four different immediate release carbamazepine products was performed. Stimulated saliva samples were collected by chewing on parafilm wax and by the spitting method. In vitro dissolution testing of formulations, using 900 mL of 1% sodium lauryl sulfate in water, was also carried out. The in vitro – in vivo correlations obtained in this salivary study were consistent with previous correlations assessed using plasma. These results support the suitability of saliva as biologic fluid in relative bioavailability studies.