CIDCA   05380
CENTRO DE INVESTIGACION Y DESARROLLO EN CRIOTECNOLOGIA DE ALIMENTOS
Unidad Ejecutora - UE
artículos
Título:
Biological effects of a complex of vanadium(V) with salicylaldehyde semicarbazone in osteoblasts in culture: mechanism of action
Autor/es:
RIVADENEIRA J; BARRIO DA; ARRAMBIDE G; GAMBINO D; BRUZZONE L; ETCHEVERRY SB
Revista:
JOURNAL OF INORGANIC BIOCHEMISTRY
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam, Holanda; Año: 2009 vol. 103 p. 633 - 642
ISSN:
0162-0134
Resumen:
Vanadium compounds display important pharmacological actions in vivo and in vitro systems. Semicarbazones are versatile ligands with therapeutic effects. Herein, we report the effects of V(V)O(2)(salicylaldehydesemicarbazone) (V(V)-Salsem) on two osteoblast cell lines in culture (MC3T3-E1 and UMR106). V(V)-Salsem inhibited cell proliferation in a dose response manner. At 100muM, the complex caused an inhibition of ca. 48% and 38% for the normal and the tumoral osteoblasts, respectively (p