CIDCA   05380
CENTRO DE INVESTIGACION Y DESARROLLO EN CRIOTECNOLOGIA DE ALIMENTOS
Unidad Ejecutora - UE
artículos
Título:
Lactobacillus casei addition to a repletion diet induced early normalization of cytokine profils during a pneumococcal infection in malnourished mice
Autor/es:
SUSANA SALVA, JULIO VILLENA, SILVIA RACEDO, SUSANA ALVAREZ, GRACIELA AGÜERO
Revista:
FOOD AND AGRICULTURAL IMMUNOLOGY
Editorial:
Taylor & Francis
Referencias:
Año: 2008
ISSN:
0954-0105
Resumen:
Abstract
This
work studied the influence of Lactobacillus
casei on cytokine production during repletion of malnourished mice in the
face of an infectious challenge. In addition, it was evaluated the number and
function of cells involved in the immune response against a respiratory
infection. Weaned mice were malnourished after consuming a protein-free diet
(PFD) for 21d. Malnourished mice were fed a balanced conventional diet for 7 d
(BCD) or BCD for 7 d with L. casei supplementation on d 6 and d 7
(BCD+Lc). The malnourished control group (MNC) received PFD while the
well-nourished control mice (WNC) consumed BCD. Mice were challenged
intranasally with Streptococcus
pneumoniae at the end of each dietary treatment. Malnutrition impaired the
levels of serum tumor necrosis factor (TNF)-a and interleukin (IL)-1b, IL-4, IL-6 and IL-10. In addition, neutrophil number and
activity, lymphocyte maturation and bone marrow CD4+, CD8+ and CD19+ cells
number, were also impaired in the MNC group. Repletion with BCD induced a
slight improvement in some of the parameters studied. However, when L. casei was added to the BCD, it was
observed a normalization of TNF-a, IL-1b and IL-6 values after
infection and an increase of the levels of IL-10 and IL-4 compared to the WNC
group. Moreover, BCD+Lc induced a significant improvement in blood and bone
marrow cells. Consequently, the use of L.
casei as a supplement in a repletion diet was associated with a pattern of
inflammatory and anti-inflammatory cytokines that led to an increased number
and functionality of the cells that participate in the immune response against
a pneumococcal infection.