Development of polyvinyl alcohol ? sodium rich Montmorillonite nanocomposites for wound healing.

VALERIA ELIZABETH BOSIO; JULIO DANIEL LAURENZA; GUILLERMO RAÚL CASTRO; MARÍA ROSA SANCHEZ TORRES; MARIELA FERNANDEZ

Trivandrum

Congreso; International Conference on New Horizons in Biotechnology (NHBT-2015); 2015

The hybrid polymer/silicate systems have mechanical, thermal, and water vapor transmission properties, which are superior to that of the neat polymer and its conventionally filled composites. In this time, nanoclyas were used like a diffusional barrier layer of Polyvinyl alcohol (PVA) cryogels for wounds healing processes to prevent dehydration and the complications during regeneration, like dressing changes procedures which involve classical retardation in cicatrization processes.A superficial barrier made of Sodium rich Montmorillonite (Na-MTT) was incorporated on the top of PVA cryogels. In addition, liposomal carriers were incorporated to carry and deliver potential bioactive molecules, like antibiotics (i.e. ciprofloxacin), to avoid classical infections for burn wounds (like Pseudomonas attack). The release behavior of Fluorescein from the PVA-Nanocomposites was study as a drug delivery model. The process was followed during 21 days, the normal time for cicatrization burn wounds.The new idea to prevent the dehydration and infections on burn and another wounds were together in this system to combat the actual problem related to dressing changes during the cicatrization process. The model drug was released in a progressive way during 21 days, and therapeutic concentrations could be reached if antibiotics replace the drug in future systems.