SYNTHESIS AND CHARACTERIZATION OF NOVEL STIMULI-RESPONSIVE HYBRID POLYMERS WITH POTENTIAL APPLICATIONS IN CONTROLLED DRUG RELEASE

FRANCISCO M. PARDINI; PAULA A. FACCIA; OSCAR R. PARDINI; JAVIER I. AMALVY

Córdoba

Congreso; 3° Reunión Internacional de Ciencias Farmacéuticas. Córdoba, Argentina, 18 y 19 de septiembre del 2014; 2014

Facultad de Ciencias Químicas, Universidad Nacional de Córdoba

In this work, hybrids containing PU polymerized with DEA (PU/DEA), NIPA (PU/NIPA) and DPA (PU/DPA) monomers were prepared and characterized using FTIR, swelling and in-vitro drug release at different pHs and temperatures, using Rhodamine 6G (Rh6G) as a model of an active pharmaceutical ingredient (API).  The results show changes in the swelling degree when the temperature or pH was modified. FTIR spectra of hybrid polymers indicate an interaction between the PU and the acrylic monomer. The PU/DEA system releases at pH 4 a large amount of Rh6G compare to pH 8. As it was expected, this behavior is also observed in the PU/DPA system in the same conditions. Additionally, this system shows a thermo-sensitive response which can be observed in the increment of Rh6G released when the temperature is modified, from 37 °C to room temperature (22 °C). For the PU/NIPA system the amount of Rh6G released was higher at 22 °C compare to 37 °C, indicating a thermo-dependence behavior. In conclusion, the copolymerization between PU and different functional acrylic monomers allows preparing hybrids polymer films with good mechanical properties and stimuli-responsive characteristics suitable for drug delivery applications. Depending on the monomer used, systems with pH or/and thermo-sensitive properties can be obtained.