Synthesis and characterization of novel stimuli-responsive hybrid polymers with potential applications in controlled drug release

F. PARDINI; P.A. FACCIA; O.R PARDINI; J.I. AMALVY

Int. J. Pharm. Sci. Res. Conference Proceeding

International Journal of Pharmaceutical Sciences and Research

Año: 2015 p. 92 - 93

Previous works have shown the stimuli- responsive characteristics of some acrylic monomers to differentchanges in the environment, like pH or temperature, which makes them useful for drug deliveryapplications. Within that group of monomers, the 2-(diethyl amino) ethyl methacrylate (DEA), the Nisopropylacrylamide(NIPA) and the 2-(diisopropylamino) ethyl methacrylate (DPA) can stand out.However depending on the conditions, films prepared from the homopolymers are brittle and difficult tohandle. A convenient way to improve the physical characteristics of films is to copolymerize with vinylterminatedpolyurethanes (PU) to produce good film-forming hybrid materials.