CIDEPINT   05376
CENTRO DE INVESTIGACIONES EN TECNOLOGIA DE PINTURAS
Unidad Ejecutora - UE
artículos
Título:
Synthesis, characterization and swelling behavior of new pH-sensitive hydrogels derived from copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino) ethylmethacrylate
Autor/es:
P.A. FACCIA; J.I. AMALVY
Revista:
JOURNAL OF APPLIED POLYMER SCIENCE
Editorial:
JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 2013 vol. 127 p. 1974 - 1980
ISSN:
0021-8995
Resumen:
The aim of this work was to synthesize and to characterize new
pH-sensitive hydrogels that can be used in the controlled release of
drugs, useful for dermal treatments or ophthalmology´s therapies.
Copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different
amounts of 2-(diisopropylamino)ethyl methacrylate (DPA) (10 and 30 wt
%) and different amounts of crosslinker agent, ethylene glycol
dimethacrylate (EGDMA) (1 and 3 wt %) were prepared by bulk
photo-polymerization. The copolymers were fully characterized by using
Fourier-transform infrared (FTIR) spectra, differential scanning
calorimetry, thermogravimetric analysis, UVvisible spectroscopy, and
measuring water content and dynamic swelling degree. The results show
that modifications in the amount of DPA and/or crosslinker in the
hydrogel produce variations in the thermal properties. When adding of
DPA, we observed an increase in the thermal stability and decomposition
temperature, as well as a change in the mechanism of decomposition.
Also a decrease in the glass transition temperature was observed with
regard to the value for pure pHEMA, by the addition of DPA. The water
content of the hydrogels depends on the DPA content and it is
inversely proportional to both the pH value and the crosslinking
degree. Pure poly-HEMA films did not show important changes over the
pH range studied in this work. The dynamic swelling curves show the
overshooting effect associated with the incorporation of DPA, the pH
of the solution, and the crosslinking density. On the other hand, no
important variations in the optical properties were observed. The
synthesized hydrogels are useful as a drug delivery pH-sensitive
matrix.