?Spexin is the new adipokine: analysis in an obese pediatric cohort in argentina

FERNANDEZ E; CARIQUIRIBORDE S; DALIERI M; GIOVAMBATTISTA A; GAMBARO, SABRINA ELIANA; FITTIPALDI ANTONELA ; OLIVERO V; HERNANDEZ J; ALZAMENDI, ANA; SALA C; GARRIDO V; ZUBIRÍA, MARÍA GUILLERMINA

Congreso; LXV Reunión Científica de la Sociedad Argentina de Investigación Clínica.; 2020

Overweight and obesity are associated with sedentary lifestyle and unbalanced diet intake. According to the last survey about nutrition and health (2019) in Argentine, 4 out of 10 children are overweight/obese. Our aim was to evaluate, in a male pediatric cohort, plasmatic levels of Spexin (SPX), Leptin (Lep) and Adiponectin (Adipo) in order to find their relationship with obesity risk factors. The study was approved by the Institutional Committee of La Plata Children?s Hospital. Physical, biochemical parameters and plasmatic adipokines from 70 children were evaluated. Patients were classified by their BMI z-score (BAZ), ranging from -1 to 1 for control (CTR), from 1 to 2 for overweight (Ow) and higher than 2 for obese (OB). Results revealed no significant differences for glucose and lipid profile, while for hepatic TGP, GGT and PCR, OB children showed higher levels than CTR. Adipo levels were similar among groups, but SPX (CTR=0,79; OW=0,53; OB=0,38 ng/mL; P