Lack of endogenous estradiol did not worsen general metabolic state nor adipose tissue function, even though adverse diet consumption

MIGUEL I; REY MA; MARTÍN FM; SPINEDI E; ALZAMENDI A; GIOVAMBATTISTA A

Mar del Plata

Congreso; LXIV Reunión de la Sociedad Argentina de Investigacion Clinica (SAIC).; 2019

SAIC

We previously studied the role of estrogen deficiency in 60 day-old female rats ovariectomized(OVX) on prepubertal age (30 day-old). It was concluded that OVX animals have improvedsome metabolic-endocrine functions. Our aim was to determine consequences of fructoserich diet (FRD) intake on female rats OVX on pre-pubertal age (age 30 days). Therefore,OVX rats were fed FRD (fructose 10% w/v in tap water) between 60-81 days of age.Thus groups studied were: animals that consumed water and chow ad libitum: control basal (CTR B), ovariectomizedbasal (OVX B), and to considering food intake by OVX animals, OVX pair-fed rats(OVX PF B) were considered; finally, rats in similar conditions but fed FRD(CTR FRD, OVX FRD, OVX PF FRD) were included. Trunkblood was collected to measure plasma metabolites and retroperitoneal adiposetissue (RPAT) pads were dissected out, weighed and processed for histologicaland gene expression analyses. FRD treatment did not increased body weight in anyrat, despite energy intake. RPAT mass decreased in OVX PF B vs CTR B animals(p