REMOTE CONTINENTAL ORIGIN OF MATERNAL LINEAGES IN THE PROVINCE OF LA PAMPA, ARGENTINA

BELTRAMO JULIETA; BRAVI CLAUDIO M; AQUILANO, ELIANA; DI ROCCO, FLORENCIA;; RODRIGIEZ GOLPE, DANIELA; BAILLIET G

Caxias do Sul

Workshop; Escola Latino-Americana de Genética Humana e Médica 2018; 2018

Escola Latino-Americana de Genética Humana e Médica

The province of La Pampa, with 318,951 inhabitants registered in 2011, it is the third least populated in Argentina. The current provincial territory of La Pampa avoid the colonial and republican state control until its definitive military occupation and full incorporation to the rest of the country in the end of 19th century. The most recent history of its settlement is marked by military campaigns, and waves of ultramarine migrants and neighboring provinces, which together have led to a significant loss of representation of native groups against the total population.Within the frame of a doctoral thesis project that also includes the North Patagonian area, this work reports a preliminary analysis of the continental origin of mitochondrial DNA (mtDNA) lineages to the current population of the province of La Pampa, Argentina.From 319 biological samples collected in the localities of Santa Rosa (N= 247) and General Pico (N= 72) the maternal lineages were studied by PCR-APLP to determine the membership of the Native-American clades (A-D) and allochthonous (L (xM, N), M and N) of the human mitochondrial phylogeny.The contribution of Native American maternal lineages was close to 70% for both locations, a value that is similar to that reported for the neighboring province of Mendoza and lower than the Northwest and Northeast of the country where it exceeds 90 % (Motti et al 2013). In the allochthonous fraction found for Santa Rosa, 25% of the individuals have European origin and 5% African; in General Pico these values correspond to 31% and 1%, respectively.Following this line, the complete control region will be sequenced and subhaplogroup-specific mtDNA polymorphisms will be typified from a fraction of the native lineages to perform a deeper analysis, and samples will be obtained to complete the study of the North Patagonia region.