IMBICE   05372
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA CELULAR
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Paclitaxel and curcumin co-loaded mixed micelles as potential nanovehicles for breast and ovarian cancer therapy
Autor/es:
BERNABEU E; RIEDEL J; MARTINEZ C; MORETTON MA; EVELSON P; CALIENNI N.; CALABRO V; PRIETO J; GONZALEZ L; ALONSO S; MONTANARI J; CHIAPPETTA DA
Lugar:
Buenos Aires
Reunión:
Jornada; XX Jornadas anuales de la Sociedad Argentina de Biología y XVII Jornadas de la Sociedad Uruguaya de Biociencias; 2018
Resumen:
Breast and ovarian cancer represent the first and the fifth cause of death among women worldwide. Paclitaxel (PTX) is one of the most effective antineoplastic drugs against breast and ovarian cancer while curcumin (CUR), a well known antioxidant agent, has been also proposed as a potential antineoplastic drug. In this context, we aimed to explore the potential of a nanotechnological platform based in mixed polymeric micelles (PMs) to co-encapsulate paclitaxel (PTX) and curcumin (CUR), employing two commercially available biopolymers as Soluplus® and d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS). This multifunctional nanocarrier could overcome the poor water-solubility of PTX and minimize one of its main side effects as the peripheral neuropathy, due to the incorporation of CUR, as an attempt to optimize breast and ovarian cancer therapy. In the first place, the PMs could successfully encapsulate both drugs (2 mg/mL of PTX and CUR) where the drug-loaded PMs exhibited a narrow size distribution with a hydrodynamic diameter of 96.0±1.2 nm. In a second step, the encapsulation of CUR within PMs did not affect its antioxidant activity. Indeed, PTX-CUR-loaded micelles showed a significant increment (p