THE BLOOD-CEREBROSPINAL FLUID (CSF) BARRIER TRANSPORTS CIRCULATING GHRELIN INTO THE BRAIN

CABRAL, AGUSTINA; PERELLO, MARIO; DE FRANCESCO, PABLO NICOLÁS; GARCÍA ROMERO, GUADALUPE; URIARTE, MAIA; FERNÁNDEZ, GIMENA

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Ghrelin is a 28-aminoacid octanoylated peptide hormone secreted from the stomach that mainly acts in the central nervous system to regulate food intake and neuroendocrine axis. However,the accessibility of plasma ghrelin to the brain is limited and restricted to few specific brain areas.The goal of this study was to gain insights into the systems mediating the transport of circulating ghrelin to the brain in mice.For this purpose,we used a fluorescent ghrelin tracer(F-ghrelin) and other fluorescent ghrelin-related analogs,that were centrally or peripherally injected to mice and mapped their distribution with in theblood-cerebrospinal fluid barrier (the choroid plexus,CP,and the tanycytes of the median eminence,ME).