IMBICE   05372
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA CELULAR
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Topical delivery of polyphenols, anthocyanins and essential lipids in nanosystems
Autor/es:
JORGE MONTANARI; SILVIA DEL VALLE ALONSO
Reunión:
Conferencia; VI International Conference on Polyphenols and Health; 2013
Resumen:
Topical delivery of polyphenols, anthocyanins and essential lipids in nanosystems Montanari J, Alonso S, LBM, Depto. C. y T., Universidad Nacional de Quilmes, R.S. Peña 352, (1878) Bernal (Bs.As.). GBEyB ? IMBICE - CONICET, Argentina. Ultradeformable liposomes (UL) are lipidic vesicles designed to penetrate across the stratum corneum (SC) driven by the transepithelial humidity gradient and to release their content to deeper skin layers. If loaded with antioxidants like polyphenols or anthocyanins, UL become potential tools for skin protection against damage from free radicals. An ethanolic extract from blueberry (Vaccinium myrtillus) was loaded into UL to obtain UL-B, which retained an 85 % of the antioxidant capacity of the extract, with low cytotoxicity. On the other hand, Nanostructured Lipid Carriers (NLC) are nanoparticle systems obtained by mixing under certain conditions a solid lipid with a spatially incompatible liquid lipid. NLC increase humidity in the skin by occlusive effect due to their nanometric size. They also act as a depot for the slow release of actives into the skin. An essential oil from lemon was used as liquid lipid itself to form NLC-L. Essential oils from citrics are rich in Omega-3 and Omega-6 lipids, needed as precursors for reconstitution of plasma membrane of damaged skin cells and ceramides in the SC. These two nanosystems were also combined in a single formulation, in order to provide their benefits together to the skin as a cosmetic/skin repair product