IMBICE   05372
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA CELULAR
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Population Structure and Genetic Diversity in Argentinean populations
Autor/es:
MUZZIO M; MOTTI JMB; KENNY E; JURADO-MEDINA LS; YEE MC; BELTRAMO J; SANTOS R; COOKE T; RAMALLO R; SCHAWB M; CORNEJO O; BAILLIET G; BRAVI CM; BUSTAMANTE CD
Lugar:
San Francisco
Reunión:
Congreso; 62nd Annual Meeting of the American Society of Human Genetics; 2012
Institución organizadora:
American Society of Human Genetics
Resumen:
Argentina was one of the last places peopled when humans entered the
Americas. Its earliest archeological sites are dated from ~13K years b.p.,
and throughout its history the region has exhibited broad cultural diversity,
involving both hunter-gatherer and agro-pastoral societies, different linguistic
families, the Southern expansion of the Inca Empire, the arrival of the
Spanish conquistadors and slave trade from Africa. More recently, Argentina
has had the highest proportion of influx of transoceanic migration between~13K years b.p.,
and throughout its history the region has exhibited broad cultural diversity,
involving both hunter-gatherer and agro-pastoral societies, different linguistic
families, the Southern expansion of the Inca Empire, the arrival of the
Spanish conquistadors and slave trade from Africa. More recently, Argentina
has had the highest proportion of influx of transoceanic migration between
~1850 and 1940 of any Latin American country. Furthermore, the geographical
distribution of immigrants was oriented towards the Pampa region of
central-eastern Argentina and the Northeast, so different patterns of mixed
ancestry throughout the country are expected. In this present work we aim
to describe the history and structure of the Argentinean population. Thus far,
we have collected DNA samples from 2904 participants from 15 dispersed
regions in Argentina, from the Andean populations in the Northwest to the
river lands of the Northeast. Our preliminary data includes genome-scale
Illumina Exome Array 250K genotypes, plus next-generation sequencing
data from uniformly spaced genomic regions targeted with a genotype-bysequencing
strategy (which covers 1.5% of the genome), for 375 participants
from 9 of the 15 populations. We will identify proportions and patterns of
European, African and Indigenous American ancestry in the Argentinean
cohort via local ancestry inference. The first series of analyses will focus
on genomic tracts of Indigenous American ancestry for fine-scale examination
of sub-continental structure by comparing to a panel of 493 samples
from 52 Indigenous American populations from throughout the Americas.
Furthermore, this work will serve as a test of different low-cost strategies
(exome genotype array vs. genotype-by-sequencing) for accurate inference
of population structure in extant populations.1850 and 1940 of any Latin American country. Furthermore, the geographical
distribution of immigrants was oriented towards the Pampa region of
central-eastern Argentina and the Northeast, so different patterns of mixed
ancestry throughout the country are expected. In this present work we aim
to describe the history and structure of the Argentinean population. Thus far,
we have collected DNA samples from 2904 participants from 15 dispersed
regions in Argentina, from the Andean populations in the Northwest to the
river lands of the Northeast. Our preliminary data includes genome-scale
Illumina Exome Array 250K genotypes, plus next-generation sequencing
data from uniformly spaced genomic regions targeted with a genotype-bysequencing
strategy (which covers 1.5% of the genome), for 375 participants
from 9 of the 15 populations. We will identify proportions and patterns of
European, African and Indigenous American ancestry in the Argentinean
cohort via local ancestry inference. The first series of analyses will focus
on genomic tracts of Indigenous American ancestry for fine-scale examination
of sub-continental structure by comparing to a panel of 493 samples
from 52 Indigenous American populations from throughout the Americas.
Furthermore, this work will serve as a test of different low-cost strategies
(exome genotype array vs. genotype-by-sequencing) for accurate inference
of population structure in extant populations.