IMBICE   05372
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA CELULAR
Unidad Ejecutora - UE
artículos
Título:
Insulin resistance and Gestational Hypertension: A Preliminary Study in a small population of La Plata Municipality (MULP)
Autor/es:
CASTROGIOVANNI D; SPINEDI E; ROMERO J; SPINEDI E; SUÁREZ-CRIVARO, FLORENCIA; SUESCUN MO
Revista:
Acta Bioquímica Clínica Latinoamericana
Editorial:
FBA
Referencias:
Lugar: CABA; Año: 2018 vol. 52 p. 23 - 32
ISSN:
1851-6114
Resumen:
Pregnant women with impaired insulin sensitivity are at risk for developing hypertensive disorders. By using a cut-off at 2.64 of the homeostasis model assessment (HOMA-IR) in basal condition (HOMA-0), we split our population study (n = 154 pregnant women) into two groups: 1) with basal HOMA-0 < 2.64 (non-insulinresistant; n = 113) and 2) with basal HOMA-0 > 2.64 (insulinresistant; n = 41). We analyzed glucose and insulin circulating levels throughout a 2-h oral 75 g glucose tolerance test (OGTT). The relationship between several parameters related to insulinresistance and the prevalence of pregnancy-induced hypertensive disorders was analyzed. Pregnant women (on week 24-28) were submitted to an OGTT, and glucose and insulin plasma concentrations were measured throughout the test. These peripheral metabolites levels and, the values of the HOMA-IR and the glucose to insulin ratio (G:I) were analyzed. Anthropometric parameters and pregnancy outcome were recorded. Women with HOMA-0 > 2.64 but normal fasting glycemia showed higher insulinemias, G:I values and HOMA-IR values at both times of the OGTT. The later women were at greater risk for developing late pregnancy-induced hypertension compared to women with HOMA-0 < 2.64.