IMBICE   05372
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA CELULAR
Unidad Ejecutora - UE
artículos
Título:
Porous Materials in the Bioprocessing Area
Autor/es:
MIRNA LORENA SANCHEZ; MARCELO FERNANDEZ LAHORE; GRASSELLI, M.
Revista:
Journal of Bioprocessing & Biotechniques
Editorial:
OMICS International Journals
Referencias:
Año: 2015 vol. 5 p. 2 - 2
ISSN:
2155-9821
Resumen:
The modern life science industry is facing a real challenge to deliver new products to a highly demanding and regulated market. As a consequence, bioprocess technology options have become limited considering total available manufacturing capacity and process efficiency and cost. The bioprocess technology can be divided into two main parts, namely upstream (fermentation) and downstream (separation and purification).A critical analysis of the current bioprocess technology reveals that the fermentative processes are in a mature phase and numerous technological developments in heterologous protein expression are already being used.Rapid developments in biotechnology and the pharmaceutical potential of biomolecules are fueling demand for reliable, efficient methods to purify preparative amounts of proteins, peptides and nucleic acids. The recovery and purification of bio products is based on chromatographic separations. However, it still has a significant number of challenges to be solved.