IMBICE   05372
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA CELULAR
Unidad Ejecutora - UE
artículos
Título:
Does the relationship between prenatal care and birth weight vary by oral clefts? evidence using South American and United States samples
Autor/es:
NYARKO KA; LOPEZ-CAMELO JS; CASTILLA EE; WEHBY GL
Revista:
JOURNAL OF PEDIATRICS
Editorial:
MOSBY-ELSEVIER
Referencias:
Año: 2013 vol. 162 p. 42 - 49
ISSN:
0022-3476
Resumen:
Objective
To evaluate if the association between prenatal
care use and birth weight (BW) varies for infants with cleft lip and/or
cleft palate (CL/P), classified into isolated and non-isolated forms,
compared with unaffected infants.
Study design
The study
employed 2 datasets. The first included a multi-country sample of 2405
infants with CL/P and 24 046 infants without CL/P born in 1996-2007 in
South America. The second was a sample of 2122 infants with CL/P and
297 415 without CL/P from the United States 2004 natality dataset.
Separate analyses were performed for the South American and United
States samples. The association between prenatal care and BW was
evaluated separately for isolated CL/P, non-isolated CL/P, and
unaffected infants using regression models adjusting for several
background characteristics.
Results
Prenatal care was
associated with improved BW for all infant groups, with greater BW
increases for infants with CL/P particularly non-isolated forms. In the
South American sample, BW increased by 108, 69, and 40 g on average per
prenatal visit for infants with non-isolated CL/P, infants with isolated
CL/P, and unaffected infants, respectively. In the United States
sample, BW increased by 51, 21, and 16 g on average per prenatal visit
for these infant groups, respectively.
Conclusions
Prenatal
care was associated with larger BW increases for pregnancies
complicated with CL/P, particularly non-isolated forms, compared with
unaffected pregnancies. Given that reduced BW is a well-recognized
comorbidity of CL/P, the findings highlight the importance of prenatal
care for at-risk pregnancies as a tertiary-prevention intervention to
reduce the health burden of CL/P.