IMBICE   05372
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA CELULAR
Unidad Ejecutora - UE
artículos
Título:
G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
Autor/es:
PRIETO MARIA JIMENA; DEL RIO ZABALA, NAHUEL; MAROTA, HERNAN; BICHARA, DARIO; SIMONETTA, SERGIO; CHIARAMONI, NADIA SILVIA; ALONSO, SILVIA DEL VALLE
Revista:
Nanomedicine & Biotherapeutic Discovery
Editorial:
OMICS group
Referencias:
Año: 2013 vol. 4 p. 1 - 11
Resumen:
Dendritic polymers are considered as emerging and outstanding carriers as modern medicinal systems due
to their derivatisable branched architecture and possibility to modify them in numerous ways. Here, G4.5 PAMAM
dendrimers were obtained as carriers of the antipsychotic drug risperidone. Despite their extensive applicability in
the pharmaceutical field, the use of dendrimers as carriers in biological systems is constrained due to their inherent
associated toxicity. The biocompatibility of dendrimers and dendrimer-risperidone complexes was evaluated in
vivo for biological performance. To this end, the pharmacokinetics and biodistribution after oral treatment of free
risperidone and dendrimer-risperidone complexes were studied in healthy mice. Also, the behavioral changes such
as locomotion, aggression, dominance in male and female mice were evaluated both after a single dose and after
daily therapy for 8 days. Also, in vivo effects of risperidone and dendrimer-risperidone complexes on the locomotion
of zebrafish larvae were explored.
The data obtained suggest that the unmetabolized risperidone complexes increase the arrival to the brain after
90 minutes. On the other hand, behavioral studies showed an increase in the potency of the drug in animals treated
with the complexes.