Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups

MARTÍNEZ-CORTÉS G; HARO-GUERRERO JO; SALAZAR-FLORES J; RUBI-CASTELLANOS R; VELARDE-FÉLIX S; MUÑOZ-VALLE JF; LÓPEZ-CASAMICHANA M; LÓPEZ-ARMENTA M; CARRILLO-TAPIA E; BRAVI CM; RANGEL-VILLALOBOS H

AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

WILEY-LISS, DIV JOHN WILEY & SONS INC

Lugar: New York; Año: 2013 vol. 151 p. 526 - 537

0002-9483

The maternal ancestry (mtDNA) has important applications in different research fields, such as evolution, epidemiology, identification, and human population history. This is particularly interesting in Mestizos, which constitute the main population in Mexico (∼93%) resulting from post-Columbian admixture between Spaniards, Amerindians, and African slaves, principally. Consequently, we conducted minisequencing analysis (SNaPshot) of 11 mitochondrial single-nucleotide polymorphisms in 742 Mestizos of 10 populations from different regions in Mexico. The predominant maternal ancestry was Native American (92.9%), including Haplogroups A, B, C, and D (47, 23.7, 15.9, and 6.2%, respectively). Conversely, European and African ancestries were less frequent (5.3 and 1.9%, respectively). The main characteristics of the maternal lineages observed in Mexican?Mestizos comprised the following: 1) contrasting geographic gradient of Haplogroups A and C; 2) increase of European lineages toward the Northwest; 3) low or absent, but homogeneous, African ancestry throughout the Mexican territory; 4) maternal lineages in Mestizos roughly represent the genetic makeup of the surrounding Amerindian groups, particularly toward the Southeast, but not in the North and West; 5) continuity over time of the geographic distribution of Amerindian lineages in Mayas; and 6) low but significant maternal population structure (FST = 2.8%; P = 0.0000). The average ancestry obtained from uniparental systems (mtDNA and Y-chromosome) in Mexican?Mestizos was correlated with previous ancestry estimates based on autosomal systems (genome-wide single-nucleotide polymorphisms and short tandem repeats). Finally, the comparison of paternal and maternal lineages provided additional information concerning the gender bias admixture, mating patterns, and population structure in Mestizos throughout the Mexican territory. Am J Phys Anthropol 151:526?537, 2013. © 2013 Wiley Periodicals, Inc.Mestizos (persons resulting from post-Columbian admixture) of 10 populations fromdifferent regions in Mexico. The predominant maternal ancestry was Native American(92.9%), including haplogroups A, B, C, and D (47, 23.7, 15.9, and 6.2%, respectively).Conversely, European and African ancestries were less frequent (5.3 and 1.9%,respectively). The main characteristics of the maternal lineages observed in Mexican-Mestizos comprised the following: 1) contrasting geographic gradient of haplogroups Aand C; 2) increase of European lineages toward the Northwest; 3) low or absent, buthomogenous, African ancestry throughout the Mexican territory; 4) maternal lineages inMestizos roughly represent the genetic makeup of the surrounding Amerindian groups,particularly in Center and Southeast, but not in the Northwest; 5) continuity over time ofthe geographic distribution of Amerindian lineages in Mayas; and 6) low but significantmaternal population structure (FST= 2.8%; p= 0.0000) defining two main clusters:Northwest and Center-Southeast. The average ancestry obtained from uniparental systems(mtDNA and Y-chromosome) in Mexican-Mestizos was correlated with previous ancestryestimates based on autosomal systems (genome-wide SNPs and STRs). Finally, this workimproves the landscape of asymmetric gene flow in Mestizos throughout the Mexicanterritory.