Polymorphisms in the fetal progesterone receptor and a calcium-activated potassium channel isoform are associated with preterm birth in an Argentinian population.

MANN PC, COOPER ME, RYCKMAN KK, COMAS B, GILI J, CRUMLEY S, BREAM EN, BYERS HM, PIESTER T, SCHAEFER A, CHRISTINE PJ, LAWRENCE A, SCHAA KL, KELSEY KJ, BERENDS SK, MOMANY AM, GADOW E, COSENTINO V, CASTILLA EE, LÓPEZ CAMELO J

JOURNAL OF PERINATOLOGY

NATURE PUBLISHING GROUP

Lugar: Londres; Año: 2012 p. 274 - 283

0743-8346

J Perinatol. 2012 Sep 27. doi: 10.1038/jp.2012.118. [Epub ahead of print] Polymorphisms in the fetal progesterone receptor and a calcium-activated potassium channel isoform are associated with preterm birth in an Argentinian population. Mann PC, Cooper ME, Ryckman KK, Comas B, Gili J, Crumley S, Bream EN, Byers HM, Piester T, Schaefer A, Christine PJ, Lawrence A, Schaa KL, Kelsey KJ, Berends SK, Momany AM, Gadow E, Cosentino V, Castilla EE, López Camelo J, Saleme C, Day LJ, England SK, Marazita ML, Dagle JM, Murray JC. Source Department of Pediatrics, University of Iowa, Iowa City, IA, USA. Abstract Objective:To investigate genetic etiologies of preterm birth (PTB) in Argentina through evaluation of single-nucleotide polymorphisms (SNPs) in candidate genes and population genetic admixture.Study Design:Genotyping was performed in 389 families. Maternal, paternal and fetal effects were studied separately. Mitochondrial DNA (mtDNA) was sequenced in 50 males and 50 females. Y-chromosome anthropological markers were evaluated in 50 males.Result:Fetal association with PTB was found in the progesterone receptor (PGR, rs1942836; P=0.004). Maternal association with PTB was found in small conductance calcium activated potassium channel isoform 3 (KCNN3, rs883319; P=0.01). Gestational age associated with PTB in PGR rs1942836 at 32-36 weeks (P=0.0004). MtDNA sequencing determined 88 individuals had Amerindian consistent haplogroups. Two individuals had Amerindian Y-chromosome consistent haplotypes.Conclusion:This study replicates single locus fetal associations with PTB in PGR, maternal association in KCNN3, and demonstrates possible effects for divergent racial admixture on PTB.Journal of Perinatology advance online publication, 27 September 2012; doi:10.1038/jp.2012.118.