IMBICE   05372
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA CELULAR
Unidad Ejecutora - UE
artículos
Título:
Fructose Rich Diet-Induced High Plasminogen Activator Inhibitor-1 (PAI-1) Production in the Adult Female Rat: Protective Effect of Progesterone
Autor/es:
CASTROGIOVANNI, D; ALZAMENDI, A; ONGARO, L; GIOVAMBATTISTA A; GAILLARD, R; SPINEDI, E
Revista:
nutrients
Editorial:
Postfach
Referencias:
Lugar: Basel; Año: 2012 p. 1137 - 1150
ISSN:
2072-6643
Resumen:
Abstract: The effect of progesterone (P4) on fructose rich diet (FRD) intake-inducedmetabolic, endocrine and parametrial adipose tissue (PMAT) dysfunctions was studied inthe adult female rat. Sixty day-old rats were i.m. treated with oil alone (control, CT) orcontaining P4 (12 mg/kg). Rats ate Purina chow-diet ad libitum throughout the entireexperiment and, between 100 and 120 days of age drank ad libitum tap water alone(normal diet; CT-ND and P4-ND) or containing fructose (10% w/v; CT-FRD and P4-FRD).At age 120 days, animals were subjected to a glucose tolerance test or decapitated. Plasmaconcentrations of various biomarkers and PMAT gene abundance were monitored.P4-ND (vs. CT-ND) rats showed elevated circulating levels of lipids. CT-FRD ratsdisplayed high (vs. CT-ND) plasma concentrations of lipids, leptin, adiponectin andplasminogen activator inhibitor-1 (PAI-1). Lipidemia and adiponectinemia were high(vs. P4-ND) in P4-FRD rats. Although P4 failed to prevent FRD-induced hyperleptinemia,it was fully protective on FRD-enhanced plasma PAI-1 levels. PMAT leptin andadiponectin mRNAs were high in CT-FRD and P4-FRD rats. While FRD enhanced PMATPAI-1 mRNA abundance in CT rats, this effect was absent in P4 rats. Our study supports