Antecedentes y nuevos aportes en el estudio del Cromosoma Y en poblaciones humanas sudamericanas

BAILLIET G; RAMALLO V; MUZZIO M; SANTOS M R; MOTTI JMB; BIANCHI NO; BRAVI CM

Basic and Applied Genetics

SOCIEDAD ARGENTINA DE GENÉTICA

Año: 2011 vol. 22 p. 1 - 9

1666-0390

ESTE TRABAJO CORRESPONDE AL CAMPO DISCIPLINAR DE LA ANTROPOLOGÍA FÍSICA (DISCIPLINADESAGREGADA 5701-ANTROPOLOGÍA FÍSICA), QUE NO SE ENCUENTRA ENTRE LAS OPCIONES A ELEGIREN LA PLANILLA DE "AREA DEL CONOCIMIENTO".The improvements in knowledge of human genome has also impact in the comprehension of the specific region of human Y-chromosome. In the last years almost 600 bialelic polymorphisms (SNP) have been described, in base of them a consistent phylogeny have been constructed, and a nomenclature have been normalized. In the present work we have analyzed 940 samples from males of 10 aboriginal populations from Argentina, Chile and Paraguay; and 12 urban populations from Argentina. Nine SNP that characterize mayor clades of the phylogeny have been analyzed, it was possible to recognize Q* and Q3 Native American haplogrups, and AB, DE, F, K, P y R foreigner haplogroups. Fst was 0.17, showing a high level of differentiation between populations. The MDS analysis showed a differentiation of aboriginal populations from urban, the stress was 0.0297 that was a good adjustment. The auto identified aboriginals and Jujuy populations showed a high proportion of Y-chromosomes from Q3 haplogroups, the Paraguayan populations differentiated from the others due they high proportion of Q* haplogroups. The urban populations were characterized by the foreigner haplogroups entering to the populations by European and others regions migrations.