Aspermicrones A-C, novel dibenzospiroketals from the seaweed-derived endophytic fungus Aspergillus micronesiensis

THI HONG HA, TRAN; NHIEM, NGUYEN XUAN; KOPPRIO, GERMAN; LUYEN, NGUYEN DINH; CUONG, LE HUU; TAI, BUI HUU; VAN KIEM, PHAN; HUONG, LE MAI; THI HAI YEN, DUONG; GARDES, ASTRID

JOURNAL OF ANTIBIOTICS

JAPAN ANTIBIOTICS RESEARCH ASSOC

Año: 2019 vol. 72 p. 843 - 847

0021-8820

Chemical investigation of the Kappaphycus alvarezii-derived endophytic fungus Aspergillus micronesiensis lead to the isolation of three novel dibenzospiroketals, aspermicrones A-C (1-3). Their chemical structures were determined by extensive analysis of HR-ESI-MS and NMR spectral data. The absolute configurations of them were determined by experimental and TD-DFT theoretical calculated circular dichroism spectra. Compound 2 exhibited selective cytotoxic effect toward HepG2 cell line (IC50 = 9.9 μM). Additionally, both of compounds 2 and 3 displayed anti-microbial activity against Staphylococcus aureus (MIC = 123.2 μM for each compound). Compound 1 was inactivity in both cytotoxic and antimicrobial assays.