IMEX   05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Simultaneous stimulatory and inhibitory effects of an anti-tumor vaccine depending on the size of the tumor target
Autor/es:
CHIARELLA, PAULA; DUARTE, ALEJANDRA; MONTAGNA, DANIELA R.; RUGGIERO, RAÚL A.
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión Conjunta de Sociedades de Biociencias 2019; 2019
Resumen:
SIMULTANEOUS STIMULATORY AND INHIBITORY EFFECTS OF AN ANTI-TUMOR VACCINE DEPENDING ON THE SIZE OF THE TUMOR TARGETImmune-checkpoint inhibitors and antitumor vaccines may produce both tumor inhibitory and tumor-stimulatory effects on growing tumors depending on the stage of tumor growth. These paradoxical results might be explained assuming the hypothesis of tumor immunostimulation according to which the inhibition or stimulation of tumor growth would be dependent on the ratio between the number of immune reactants and the number of tumor cells. To test this claim, we studied the effect of an anti-tumor vaccine administered to mice bearing both a relatively large primary tumor and a small secondary tumor implant. The tumor used was the strongly immunogenic methylcholanthrene-induced MC-C fibrosarcoma and the anti-tumor vaccine was prepared with lethally irradiated MC-C tumor cells. Mice bearing a primary tumor exceeding 500 mm3, received simultaneously the vaccine and the secondary tumor implant. Tumor volumes of both the primary and secondary tumors was determined at different times after the vaccine. The vaccine produced a significant enhancement of the primary tumor (mean of six independent experiments; p