IMEX 05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
PROTEIN A-TNFR1 INTERACTION MODULATES NEUTROPHIL SIGNALLING AND SURVIVAL IN RESPONSE TO STAPHYLOCOCCUS AUREUS
Autor/es:
GAROFALO AILIN; KEITELMAN IRENE; LEDO CAMILA; SABBIONE FLORENCIA; GOMEZ MARISA; GONZALEZ CINTIA; TREVANI ANALIA
Lugar:
SAN MIGUEL DE TUCUMAN. TUCUMAN
Reunión:
Congreso; SAI-2019-LVII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA; 2019
Institución organizadora:
SAI
Resumen:
The TNF receptor 1 (TNFR1) initiates pro-inflammatory and apoptotic signalling cascades in neutrophils. Considering that TNFR1 signals S. aureus protein A (SpA), the aim of this study was to explore the interaction of SpA with neutrophils to underscore signalling pathways that may modulate their lifespan during staphylococcal infections. Human neutrophils were stimulated with S. aureus or an isogenic SpA deficient mutant (SpA-). Production of IL-8 (p
