IMEX   05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
THE ROLE OF SPHINGOSINE KINASES ON CHRONIC LYMPHOCYTIC LEUKEMIA
Autor/es:
ELÍAS ESTEBAN; RISNIK DENISE; CRANCO SANTIAGO; AIZPURDUA FLORENCIA; GIORDANO MIRTA; VERGARA-RUBIO, MARICEF; COLADO ANA; BEZARES FERNANDO; MAHUAD CAROLINA; BORGE MERCEDES; CORDINI, GREGORIO; MORANDE PABLO; AVALOS SANCHEZ JULIO; ZERGA MARTA; GAMBERALE ROMINA
Lugar:
Mar del Plata
Reunión:
Congreso; LXVI Reunión Anual de la Sociedad Argentina de Inmunología (SAI-SAIC-SAFIS); 2018
Resumen:
Sphingosine kinases (SK1 and SK2) produce sphingosine-1-phosphate which mediates cell growth,survival and differentiation, amongother functions. We previously reported that inhibition of SK1by the commercial inhibitor SKI-II, reduces leukemic cell survival, activationand proliferation inCLL patients (Almejún, Haematologica-2017).The aims of this study were: 1) to evaluate the effectof SKI-II onnon-leukemic lymphocytes, and 2) to determine whether SK2 regulates leukemic cellsurvival. Then, peripheral blood mononuclearcells (PBMC) from CLL patients were cultured withdifferent doses ofSKI-II, and NK and T cell viability was evaluated by flow cytometricalterationsof light-scattering properties at 24hs. We found that SKIII reduces T and NK cell survival in a dosedependent way (n=15,p