A CORNEAL INJURY IN ONE EYE LEADS TO DISRUPTION OF MUCOSAL TOLERANCE IN THE OPPOSITE OCULAR SURFACE THROUGH A TRPV1- AND SUBSTANCE P-DEPENDENT NEUROINFLAMMATORY CIRCUIT

MIGLIO RODRIGUEZ, MAXIMILIANO S.; SABBIONE, FLORENCIA; GALLETTI, JEREMIAS G.; KEITELMAN, IRENE; GIORDANO, MIRTA N.; GUZMÁN, MAURICIO; TREVANI, ANALIA S.

Buenos Aires

Congreso; Reunión conjunta de Biociencias; 2017

SAI-SAIC-SAIB

(883) A CORNEAL INJURY IN ONE EYE LEADS TODISRUPTION OF MUCOSAL TOLERANCE IN THE OPPOSITEOCULAR SURFACE THROUGH A TRPV1- ANDSUBSTANCE P-DEPENDENT NEUROINFLAMMATORYCIRCUITMaximiliano Sebastián Miglio Rodríguez, Mauricio Guzmán,Irene Kaitelman, Florencia Sabbione, Analía Trevani, MirtaGiordano, Jeremías GallettiInstituto de Medicina ExperimentalBoth ocular surfaces are considered functionally independent,thus an injury to one cornea is not expected to affect the oppositeeye. However, we have observed that the tolerogenic immune responseobserved in mice after exposing one ocular surface to a foreignantigen is prevented if the opposite cornea is injured. Here weexplored the underlying mechanisms for such inter-eye influence.First, we observed an increase in NFκB signaling in the conjunctivalepithelium of the opposite eye (p