PLATELETS ACT AS CARRIER OF B. abortus TOWARDS MONOCYTES, PROMOTING THEIR INFECTION AND THEIR PRO-INFLAMMATORY CAPACITY

MILILLO, M. AYELÉN; LANDONI, VERONICA I.; BARRIONUEVO, PAULA; VELASQUEZ, LIS N.; RODRIGUEZ, ANA M.; POZNER, ROBERTO G.; TROTTA, ALDANA; DELPINO, M. VICTORIA; GIAMBARTOLOMEI, GUILLERMO H.

Buenos Aires

Simposio; Frontiers in Bioscience 3; 2018

Max Planck

Brucellosis is an infectious disease elicited by bacteria of the genus Brucella. Platelets have been recently involved in the modulation of both innate and adaptive immune responses. Although many interactions have been described between B. abortus and monocytes/macrophages, the role of platelets during the infection remained unknown. Thus, the aim of this study was to investigate the role of platelets in the immune response against B. abortus. We first focused on the possible interactions between B. abortus and platelets. Our results showedthat platelets were able to interact with bacteria in a dose-dependent fashion. Moreover, this interaction triggered platelet activation, measured as fibrinogen binding and P-selectin expression (p