ACIDIC PRECONDITIONING OF ENDOTHELIAL PROGENITOR CELLS IMPROVED SURVIVAL AND BLOOD FLOW RESTORATION AFTER ISCHEMIA IN TYPE II DIABETIC MICE.

SCHATTNER M; NEGROTTO S; MENA HA; ZUBIRY PR

Buenos Aires

Congreso; Reunion Conjunta de Sociedades Biomédicas; 2017

We demonstrated that acidic preconditioning exacerbates angiogenic responses of human late outgrowth endothelial progenitor cells (EPC). We now aimed to analyze whether this strategy also improves EPC survival and functionality in the presence of damage signals (DAMPs) highly augmented in ischemic milieu or in diabetes, where tissue regeneration is compromised. Cord blood-derived EPC were exposed at pH 6.6 for 6 h (preconditioned) or pH 7.4 (control) and then pH was restored at 7.4. N=5-7, *p