IMEX   05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Brucella abortus-activated microglia induce neuronal death through primary phagocytosis.
Autor/es:
MIRIAM M. COSTA FRANCO; SERGIO C OLIVEIRA; ANA MARIA RODRIGUEZ; BARRIONUEVO PAULA; MARIA VICTORIA DELPINO; M. CRUZ MIRAGLIA; VIDA DENNIS; GUILLERMO H. GIAMBARTOLOMEI
Lugar:
Mar del Plata
Reunión:
Congreso; 65. LXIV Reunión Anual de la Sociedad Argentina de Inmunología (SAI). 15-19 Noviembre 2016.; 2016
Institución organizadora:
Sociedad Argentina de Inmunología
Resumen:
Central nervous system invasion by bacteria of the genus Brucellaresults in an inflammatory disorder called neurobrucellosis. B.abortus infects microglia, eliciting their activation and production ofpro-inflammatory mediators. Evidence of neurological involvementoccurs to varying degrees in nervous systems of patients withneurobrucellosis. The aim of this work was to determine the putativemechanisms involved in this phenomenon. For this, we usedmurine primary cultures of neurons and microglia to demonstratethat, due to B. abortus infection, microglial primary phagocytosisactively induces neuronal death, without inducing neuronal apoptosis.This phenomenon was due to microglia-TLR2 activation byBrucella lipoproteins. We demonstrated that B. abortus-activatedmicroglia secrete nitric oxide (NO) and increase their phagocyticability and proliferation (p