IMEX   05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A B-cell superantigen induces the apoptosis of murine and human malignant B cells
Autor/es:
MUNDIÑANO JULIANA; ALEMAN MECEDES; LORENZO DANIELA; SIELECKI ALEJANDRO; DUARTE ALEJANDRA; BERGER PAULA; PIAZZON ISABEL; NEPOMNASCHY IRENE
Lugar:
Mar del Plata
Reunión:
Congreso; reunion anual de la sociedad Argentina de Investigacion clinica; 2016
Institución organizadora:
SAI-SAIC-SAFE
Resumen:
B-cell superantigens (Sags) are bacterial and viral proteins which affect immune responsiveness binding conserved sites of the VH or VL regions of immunoglobulin molecules outside their complementarity-determining regions inducing apoptosis of normal cognate B cells. We had demonstrated that T-cell Sags induce the apoptosis of cognate malignant T cells.Exposure to bacterial and retroviral T Sags in vivo increases lymphoma-bearing mice survival. In the present study we investigated whether protein L (PpL), a B-cell Sag that interacts with κ+ bearing cells are able to induce the apoptosis in spontaneous murine lymphoma B cells and human Daudi cells. Results: PpL induced apoptosis (measured by Annexin V-FITC) in murine κ+lymphoma B both in vitro (p