Corneal injury in one eye disrupts mucosal immune tolerance of the fellow ocular surface by inducing substance P-mediated neurogenic inflammation

KEITELMAN IRENE; GIORDANO MIRTA NILDA; KEITELMAN IRENE; GIORDANO MIRTA NILDA; SABBIONE FLORENCIA; GALLETTI JEREMÍAS GASTÓN; GUZMÁN MAURICIO; SABBIONE FLORENCIA; TREVANI ANALÍA SILVINA; GALLETTI JEREMÍAS GASTÓN; GUZMÁN MAURICIO; TREVANI ANALÍA SILVINA

Congreso; LXIV REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA; 2016

Sociedad Argentina de Inmunología

In the clinic, it is commonly accepted that both eyes are functionally independent, but we unexpectedly observed immune tolerance perturbations in the opposite eye after unilateral manipulation in mice. Since there is no ocular lymphatic cross drainage that could account for this contralateral change, we studied the effect of a unilateral corneal lesion on conjunctival mucosal tolerance of the fellow eye. Using a delayed-type hypersensitivity (DTH) assay after s.c. immunization with ovalbumin (OVA)+adjuvant in Balb/c mice, we observed observed reduced responses in OVA-instilled mice compared with control mice (p