IMEX   05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Ascorbic acid on platelet function. New functions for an old drug.
Autor/es:
MARTI, MARCELO A.; SUAREZ, SEBASTIAN; POZNER, ROBERTO G.; IVANI, PAOLA C.; SCHATTNER, MIRTA
Lugar:
Mar del Plata
Reunión:
Congreso; LXI Reunión anual de la SAIC; 2016
Institución organizadora:
SAIC
Resumen:
Early studies have shown that ascorbic acid (Asc), the reduced form of vitamin C, inhibits platelet (Plt) aggregation partly by reducing the levels of reactive oxygen species. However, recent studies revealed that excessive vitamin C consumption may aggravate cardiovascular diseases in susceptible populations. To further characterize the mechanisms of Asc on Plt activation, in this study we evaluated some activation responses of Plt at normal or low concentration of the classical agonist PAR-1-agonist peptide (AP) or arachidonic acid (AA) in the presence of Asc, and the possible implication of HNO, a new reactive nitrogen species of biological interest.In line of previous reports, Plt aggregation induced by AA 0.9mM or PAR1-AP 6µM were significantly inhibited when Asc 10mM was added to the cuvette of a light transmission aggregometer (49±10 or 24±9% of inhibition for AA 0.9mM or PAR1-AP 6µM, respectively, p