PO180-TUE FXI and FXII activity levels in young patients with cryptogenic ischemic stroke

DUBOSCQ C; CERESETTO JM; STEMMELIN G; SHANLEY C; RABINOVICH O ; PALMER S; BULLORSKY E; AISYF RESEARCH GROUP; SÁNCHEZ LUCEROS A

Toronto

Congreso; XXV Congress of the International Society on Thrombosis and Haemostasis and 61st Annual SSC Meeting.; 2015

International Society on Thrombosis and Haemostasis

Background: Experiments with Factor XII (FXII) knockout mice have demonstrated that fibrin formation mediated by FXII and FXI is important for pathological arterial thrombosis. These studies have also showed that FXII deficiency prevents pathological thrombus formation without affecting normal haemostasis. However, it is unknown if FXII and FXI contribute to stroke pathophysiology in humans.Aims: The aim of this study is to determine FXI and FXII activity levels in young people with stroke.Methods: Population: Stroke Group (SG): 37 consecutive patients (22-55 years old) with cryptogenic arterial cerebrovascular disease confirmed by image studies were included between 2010 and 2014 as part of a Multicenter National Study for the detection of Fabry disease in young people (AISYF trial). A CT scan, MRI, carotid ultrasonography and transthoracic echocardiography and EKG monitoring wasperformed in all patients. 15/37 present at least one classical cardiovascularrisk factor and all had a negative thrombophilia study. Mean NIHSS score was 4 (1-7). Control group (CG): 70 healthy controls.Method: FXI and FXII were performed in three dilutions by one stage clotting assay in automated coagulometer.Results: Stroke group mean age was 41.9 years old (range: 22-55), 22 women; Control group mean age was 38 years old (25-50),18 women. FXI activity levels were SG: 121.12 28.32% and CG: 101.74 12.58%. Three patients presented FXI levels above 90 th percentile of control group. FXII activity levels were: SG:116.57 34.83% and CG: 102 18.32%. Seven patients showed FXII levels above 90th percentile of control group. In this study, neither FXI nor FXII activity levels in the stroke group were significantly different from the control group.Conclusion: According with these results, FXI and FXII activity levels doesn?t appear to be associated with cryptogenic ischemic stroke.