INTERLEUKINS PLASMA LEVELS IN HIV/HCV COINFECTED PATIENTS WITH OR WITHOUT ANTIRETROVIRAL THERAPY

BADANO NOEL; PARODI CECILIA; ALOISI NATALIA; MONZANI CECILIA; CORTI MARCELO; NEME DANIELA; DE E DE BRACCO M MARTA; BARÉ PATRICIA

Buenos Aires

Congreso; IV Congress of LASID; 2015

IL-10 and IL-2 plasma levelswere analyzed by ELISA in a cohort of HIV/HCV-coinfected hemophilic patients.Patients were classified as those who received continuous antiretroviraltherapy (ART) for more than 15 years, showing good adherence and response (G1,n=15) and those who did not initiate ART or showed poor adherence or noresponse (G2, n=16); 9 of which subsequently died. Samples from healthy donors(C1) and from non-infected hemophilic patients (C2) were used as controls.Statistical analysis was performed with Student t test and Mann Whitney.No significant differences were observed between G1 and controls in IL-2 (G1:3.7; C1: 4.5; C2: 4.0 pg/ml) and IL-10 levels (G1: 6.9; C1: 7.5; C2: 6.2pg/ml). However, within G1, IL-10 values were significantly lower compared tothe pre-ART stages (10.7 vs 6.4 pg/ml; p=0.001). Instead, G2 showedsignificantly higher IL-2 (6.1 pg/ml) and IL-10 (14.1 pg/ml) levels thancontrols and G1 (p=0.01). As expected, G1 displayed higher CD4 counts and lower HIV viral load than G2.The analysis of interleukins levels in relation to immunological andvirological status showed a negative correlation with CD4 counts (r=-0.5;p=0.01) and a positive correlation with viral load (r=0.5; p=0.01).Continuous and good adherence to ART is not only necessary to achieve viralcontrol but it may also contribute to the immune restoration by reverting CD4counts and cytokine production.Changes in interleukins plasma values deserve further investigation since thefollowing of these biomarkers could be useful as predictors for clinicaldisease progression in HIV/HCV patients.