ANTITUMOR AND ANTI-MIGRATORY EFFECTS OF LURBINECTEDIN ON B-CELL FROM CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS.

RISNIK D; PODAZA E.A; DE LOS RIOS ALICANDU M; COLADO A; ALMEJUN MB; BEZARES FR; FERNANDEZ GRECCO H; CABREJO M; BORGE M; GALMARINI C; GAMBERALE R; GIORDANO M

Buenos Aires

Congreso; LASID FAI SAI 2015; 2015

Chronic lymphocytic leukemia (CLL) isthe most frequent leukemia in adults and, despite recent advancesin therapy, it remains incurable. Novel treatments should affectboth, neoplastic B-cells and protective microenvironment inlymphoid tissues. Lurbinectedin (Lur) is a synthetic alkaloid thatbinds covalently to DNA and is currently in phase I/II clinicaltrials for solid and hematological tumors. The aims of this studywere to evaluate the cytotoxicity of Lur on circulatingmononuclear cells (PBMC) from CLL patients and healthy donorsand to determine if it affects the in vitro migration of leukemic Bcells.Methods and Results: Flow-cytometry analysis revealed that Lurinduced a dose- and time-dependent death with higher sensitivityfor CLL over healthy donors PBMC (% apoptosis control vs Lurp