Epidemiological and prognostic factors from the Argentinean MDS registry

GONZALEZ, JACQUELINE; FLORES, GABRIELA; ARBELBIDE, JORGE; IASTREBNER, MARCELO; NUCIFORA, ELSA; ENRICO, ALICIA; PRATES, M VIRGINIA; ROSENHAIN, MARIANA; KORNBLIHTT, LAURA; CRISP, RENÉE; ALFONSO, GRACIELA; BASQUIERA, ANA L; MARTÍN, CARLOS; SANTOS, ISABEL; BARCALÁ, VIRNA; BELLI, CAROLINA

Washington

Simposio; 13th International Symposium on Myelodysplastic Syndromes; 2015

Myelodysplastic Foundation

Argentinean MDS Registry was created in 2008 and is sponsored by The Argentinean Society of Hematology. The main objective was to collect MDS related data to describe epidemiological characteristics, prognostic factors and scoring risk stratifications.After 7 years , 14 institutions from Argentine, have been reporting data from 532 patients (89% with de novo MDS) diagnosed mostly since 2007. Median age was 72 (17-95) years with a gender ratio (M/F) of 1.3. During follow-up (mean: 18 months, range: 1-129 m), 104 (19.5%) evolved to AML and 211(39.7%) died.Age, sex, bone marrow blast percentage, hemoglobin level, platelet and neutrophil counts, karyotype, LDH level, ferritin levels, myelofibrosis and red blood cell transfusion requirement were significant predictive variables for prognosis (Kaplan-Meier and Long-Rank test, p