IMEX   05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Extracellular histones exert a differential cytotoxic and antiangiogenic effect in progenitor and mature endothelial cells.
Autor/es:
MENA HA; CARESTIA A; SCHATTNER M; NEGROTTO S
Lugar:
Toronto
Reunión:
Congreso; ISTH Congress; 2015
Institución organizadora:
ISTH
Resumen:
Background: Histones are main components of neutrophil extracellular traps, which are highly augmented not only in infection but also in sites of neovessel formation, like peritumoral and regeneration tissues. Extracellular histone cytotoxic effect on endothelial cells has been previously studied, although the mechanism involved are not fully understood. Aims: To further analyze histone cytotoxicity in endothelial cells and whether histones affect endothelial angiogenic functions. Methods: Endothelial cells from micro (HMEC1) and macrovascular (HUVEC) beds and late outgrowth endothelial colony forming cells (ECFC) were treated with individual human recombinant histones. P